Genetic mutations in accordance with a low malignant potential tumour are not demonstrated in clear cell papillary renal cell carcinoma

Maria Rosaria Raspollini1, Francesca Castiglione1, Liang Cheng2, Rodolfo Montironi3, Antonio Lopez-Beltran4,5

1.Department of Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy
2.Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
3.Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
4.Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain
5.Champalimaud Clinical Center, Lisbon, Portugal

Clear cell papillary renal cell carcinoma (CCPRCC) cases were evaluated for mutations on the following genes: KRAS, NRAS, BRAF, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET and EGFR. Four male and three female patients of age 42–74 years were evaluated. All cases were incidentally detected by ultrasound and ranged 1.8–3.5 cm. Microscopic examination showed variably tubulopapillary, tubular acinar, cystic architecture and the characteristic linear arrangement of nuclei. The cells were reactive with CK7 (strong), CA IX (cup-shape) and 34 β E12. CD10, AMACR/RACEMASE and GATA3 were negative. There were no mutations on any of the investigated genes. This preliminary observation supports the concept that CCPRCC might be indeed an indolent tumour worth it to be named as clear cell papillary neoplasm of low potential.

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